HTPD Olympiad 2014

Based on the enthusiastic endorsement from the second high-throughput process development (HTPD) conference, the first HTPD Olympiad announced. The Olympiad allowed process developers to benchmark their internal HTPD workflows against peers in the biopharmaceutical industry and academy. The organizers were hoping to see a diversity of approaches to meet the main challenges in HTPD. The Olympiad focused on downstream processing and process analytics
Five teams were accepted for the HPTD Olympiad.

The challenge

The Olympiad comprises the development of a process for purification of a domain antibody (DAB) expressed in E. coli. Your challenge will be to use HTPD workflows in the development of a purification protocol for maximized DAB purity and yield. Your participating team will be provided with a description of the target molecule, a DAB-containing sample of clarified harvest fluid, a set of maximum five types of chromatography media (resins), and descriptions of suggested analytical methods. Your process will be assessed in four categories: (1) process performance (yield, purity); (2) data handling and modeling; (3) analytics; and (4) HTPD workflow efficiency (time, sample consumption).


The winning teams

Winners of HTPD Olympiad


The HTPD Olympiad scientific board
HTPD organizing committee

1st place in category Process Performance to

  • Genentech Inc., a member of the Roche Group
    For obtaining the highest yield at a suitable purity albeit using a three-step process

1st place in category Data handling and modeling to

  • Genentech Inc., a member of the Roche Group
    For a screening work based on mechanistic chromatographic understanding

1st place in category Analytics to

  • Merck & Co.
    For the extensive use of fast and sensitive analytical methods able to follow the high throughput workflow

Shared 2nd place

  • University College London
  • Roche Diagnostics GmbH
  • Boehringer-Ingelheim Pharma GmbH