Preliminary poster program

A Way Towards Understanding and Managing for Resin Material Variability
Eva Rosenberg (1), Per Liden (2), Peter Hagwall (2)*, Gunnar Malmquist(2), (1) Roche, Penzberg, Germany, (2) GE Healthcare, Uppsala, Sweden
Evaluation Of High Throughput Technologies For Process Characterization: A Potential To Replace AKTA Lab Scale With Robocolumns
Ashish Sharma, Catherine Grimm, Hai Hoang*, Amgen, USA
Using HTPD to Link AMBR and Purification to Assess Manufacturability of Cell Line Clones
Ryan Zolyomi*, Yu-Hsi Chang, Deepa Surendar, Xiaoyu Pan, Andrew Messer, Hendri Tjandra, Ashley Hesslein, Bayer, Berkeley, USA
Deriving More Value out of your HTPD Through Better Control of Solution Conditions
Brian D. Bowes*, William D. Holmes, M. Dane Sauffer, Lawrence H. Breen, Eli Lilly and Company, Bioprocess Research & Development, Lilly Corporate Center, Indianapolis, IN 46285, USA
Cultivation of BHK21 Suspension Cells in a Controllable 24-well Bioreactor System
Astrid Coolen, Gerco van Eikenhorst, Dinja Oosterhoff, Yvonne E. Thomassen*, Intravacc, Process Development Viral Vaccines, Bilthoven, the Netherlands
Catalytically-active Inclusion Bodies: Application of High-throughput Cultivation Technologies to Study Innovative Enzyme Aggregates
Robin Lamm (1)*, Ramona Kloss (2), Vera D. Jaeger (3), Martina Pohl (2), Ulrich Krauss (3), Karl-Erich Jaeger (3), Jochen Buechs (1), (1) Aachener Verfahrenstechnik – Biochemical Engineering, RWTH Aachen University, Forckenbeckstraße. 51, 52074 Aachen, Germany (2) Institute of Molecular Enzyme Technology, Heinrich Heine University Düsseldorf, Wilhelm Johnen Straße, 52428 Jülich, Germany (3) Institute of Bio- and Geosciences, Forschungszentrum Jülich, Wilhelm Johnen Straße, 52428 Jülich, Germany
A High Throughput Approach for a Novel Process to Implement Multimodal Resins into New Format Molecule Purification Processes
Susanne Konrad*, Moritz Bennecke, Stefan Hepbildikler, Roche Diagnostics GmbH, Penzberg, Germany
Excipient Screening for Improved Thermal Stability Using Prometheus Nano-DSF
Angela Cifelli*, Peyman Moslemy, Dupont Industrial Biosciences Palo Alto, CA, USA
Integration of Ambr High-throughput Bioreactor Systems into the USP Development Workflow and into the Data Acquisition, Management and Analysis System
Alina Schneider, Christian Schwald, Katharina Schweizer, Timo Frensing*, Roche Diagnostics GmbH, Pharma Research and Early Development, Department Cell Culture Research, Roche Innovation Centre Munich, Germany
High-throughput and Miniaturized Resin Reuse Studies
Razwan Hanif, Mariangela Spitali*, UCB Slough, UK
Rapid Process Development of a CIEX Step for a Biosimilar
Anna Maria Gudmundsdottir (1), Elizabeth Ellis (1), Andrew Falconbridge (1), Sushma Nayak (2), Charlotte Brink (2), Kristina Nilsson Valimaa (2)*, (1)Alvotech, Reykjavik, Iceland, (2)GE Healthcare, Uppsala, Sweden
Just-in-time Model Building for Fast Chromatography Process Development by Combining High Throughput Data and Mechanistic Modeling
Katharina Doninger*, Jochen Kraus, Thomas von Hirschheydt, Chris Williams, Jessica Yang, Jan Griesbach, Ferdinand Stückler, Roche Diagnostics GmbH, Penzberg, Germany
Supporting Virus-filtration Performance Testing by Robotic Methods
Alexander Kurtenbach, Marc Bieberbach, Peter Kosiol, Moritz Bennecke, Björn Hansmann, Volkmar Thom, Stefan Hepbildikler, Roche Diagnostics GmbH, Penzberg, Germany
Implementation of an Analytical Microfluidic Device for the Quantification of Protein Concentrations in a High-throughput Format
Marie-Therese Schermeyer*, Carsten P. Radtke, Jürgen Hubbuch, Karlsruhe Institute of Technology, Karlsruhe, Germany
Much-efficient and Cost-effective Manufacturing of Antibody Biotherapeutics Employing Integrated Negative Chromatography Technology
Razwan Hanif*, Mariangela Spitali, Nicola Roberts, Tara Lansink, Anna Trzuskolas, Ankit Srivastava, Chad Zhang, UCB, Slough, UK
Automation and Miniaturization of Stress Studies for Selection of Formulations for Complex Therapeutic Proteins
Frank Hämmerling*, Kai Baumgartner, Claudia Weigel, Julia Kasper, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany
Scalability of Mechanistic Models for Ion Exchange Chromatography under High Load Conditions
Thiemo Huuk (1,4), Tobias Hahn* (1,4), Jan Griesbach (2), Stefan Hepbildikler (3), Jürgen Hubbuch (4), (1) GoSilico GmbH, Karlsruhe, Germany, (2) F. Hoffmann-La Roche Ltd, Basel, Switzerland, (3) Roche Diagnostics, Penzberg, Germany, (4) Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany
Standardized High Throughput Methodology to Enable a Platform Approach to Early-Stage Downstream Process Development
Brian Murray*, Michael Coolbaugh, Tarl Vetter, Jason Walther and Kevin Brower, Sanofi, Framingham, MA, USA
Machine Learning in the Cell Line Development Stage for Identifying High Producers in Ambr15
Viktor Konakovsky* (1), Tracy Martin (1), Graham McCreath (1), Jarka Glassey (2), (1) Fujifilm Diosynth Biotechnologies,Billingham, United Kingdom, (2) School of Chemical Engineering and Advanced Materials, University of Newcastle, Newcastle upon Tyne, United Kingdom
Single-use Primary Capture Technology Delivering a New Flexibility for MAb Processing
Ian Scanlon*, Matthew Townsend, Chris Morris, Nick Daniell, Oliver Hardick, Puridify, Stevenage Bioscience Catalyst, United Kingdom
Comparison of Relative Resin Content Between Prepacked Mini- and Laboratory-scale Chromatography Columns
Tryggve Bergander, Anna Mattsson, Elin Monie*, Anna Grönberg, Eva Heldin, GE Healthcare Uppsala Sweden
Use of microscale techniques to accelerate antibody downstream process development
Mark Pearce-Higgins Razwan Hanif* Anna Trzuskolas, UCB, Slough, UK
HTPD meets PLS
Sven Claßen*, Klaus Kaiser, Joern Linkner, Bob van der Jeugt, Bayer AG, Wuppertal, PerkinElmer LAS, Rodgau, Germany
Development of high-throughput Multi-Mode Mimetic Ligand™ libraries
Ben Beacom, Jim Pearson, Elena Sirbu, Chris Sadler, Jacopo Lembo, Chloe Booth*, Prometic Bioseparations, Cambridge, UK
Model-based Pulse Feeding Experiments to Study Scale-up Effects in Milliliter Bioreactors
E. Anane*, S. Hans, F. Glauche, P. Neubauer, M. N. Cruz Bournazou, Bioprocess Engineering, TU Berlin, Germany
High Throughput Process Development for Aggregate Removal in Flow-through Membrane Chromatography
Dominik Stein* , Alexander Langsdorf ,Volkmar Thom, Sartorius Stedim Biotech GmbH, Göttingen, Germany