HTPD Olympiad 2014
Based on the enthusiastic endorsement from the second high-throughput process development (HTPD) conference, the first HTPD Olympiad announced. The Olympiad allowed process developers to benchmark their internal HTPD workflows against peers in the biopharmaceutical industry and academy. The organizers were hoping to see a diversity of approaches to meet the main challenges in HTPD. The Olympiad focused on downstream processing and process analytics
Five teams were accepted for the HPTD Olympiad.
The Olympiad comprises the development of a process for purification of a domain antibody (DAB) expressed in E. coli. Your challenge will be to use HTPD workflows in the development of a purification protocol for maximized DAB purity and yield. Your participating team will be provided with a description of the target molecule, a DAB-containing sample of clarified harvest fluid, a set of maximum five types of chromatography media (resins), and descriptions of suggested analytical methods. Your process will be assessed in four categories: (1) process performance (yield, purity); (2) data handling and modeling; (3) analytics; and (4) HTPD workflow efficiency (time, sample consumption).
The winning teams
The HTPD Olympiad scientific board