Program overview HTPD 2023
Program overview HTPD 2023 (tentative)
Monday October 30 – Pre-conference day / Start of conference
9.00 – 16.00 Registration desk open at Mediterranean Conference Center (MCC)
10.00 – 15.00 Chromatography Modeling Day (lunch included)
16.00 Conference start. Opening remarks
16.15 Opening seminar: Dr Martina Micheletti, UCL “Scale-down tools for rapid upstream process development: fundamentals and scaling approaches”
17.40 Welcome drink and opening reception at MCC
Tuesday October 31 (Mediterranean Conference Center (MCC)
8.00 – 12. 00 Smart Process Development – Modeling
Session chairs: Jürgen Hubbuch, KIT/ Tobias Hahn, Cytiva
8.00 – 8.15 Session intro
8.15 – 8.45 Adapting High-throughput Technologies for Mechanistic Modeling: Construct Model with the Combination of Kp and Robocolumn as a Novel Calibration Tool
Yanru Zhang, Chugai
8.45-9.15 Accelerating downstream process development using in-silico process optimization with mechanistic models
Gabriela Sanchez, Merck&Co
9.15 – 9.45 Mechanistic modeling of virus surrogate removal by anion exchange chromatography
Lukas Döring, Rentschler
9.45-10.15 Coffee
10.15 – 10.45 A chromatography system modeling strategy for precise in silico process scaling
Tatjana Trunzer, Cytiva
10.45 – 11.15 Creation of a Phase I/II digital twin for a mAb MMC_AEX unit operation in flow-through mode
Erik Hinze, CSL Behring Innovation GmbH
11.15 – 11.45 Simplifying the mechanistic modeling workflow with precharacterized columns – the story from their development to application
Max Edin, Cytiva
12.00-13.00 Lunch
13.00- 17.00 Evolution of Mature HTPD Platforms
Session chairs: John Welsh, Rivanna Bioprocess Solutions / Brian Murray, Sanofi
13.00-13.15 Session intro
13.15 – 13.45 Integrated Protein A Chromatography and Low pH Viral Inactivation Unit Operations Miniaturised on an Automated Platform
Paras Sharma, UCL CSL Behring
13.45 – 14.15 High Throughput Screening for resin regeneration conditions
Cornelia Walther, Boehringer-Ingelheim
14.15 – 14.45 Improved DOE Workflow for Parallel Screening Experiments on the Ambr® Crossflow TFF system
Viktor Sandner, Sartorius
14.45 – 15.15 Coffee
15.15 – 15.45 High Throughput Models for Process Characterization: Successes and Challenge
Brian Murray, Sanofi
15.45 – 16.15 Micro-scale Purification Platform – High throughput tool for BioPharma Manufacturing Investigations
Manoj Ganesh , Regeneron
17.00-19.00 Poster session
Wednesday November 1 (Mediterranean Conference Center (MCC)
9.00-12.00 Integrated PD and Analytics Case Studies
Session chairs: Jon Coffman, Astra Zeneca, / Andrea Rayat UCL
9.00 – 9.15 Session intro
9.15 – 9.45 Automated Raman spectroscopy measurements for integrated chemometric model development
Jakob Müller, KIT
9.45 – 10.15 SpecPlate, the better standard for more efficient plate based UV/Vis absorbance measurements
Carsten Radtke, PHABIOC
10.15 – 10.45 Coffee
10.45 – 11.15 Integration of Automated High Throughput Process Analytics to support High Throughput Process Development
Nicola Roberts, UCB
11.15 – 11.45 Enhancing Bioprocessing with pH Sensitive Nanosensors: High Throughput Screening and Antibody Production
Alison Tang, AstraZeneca
12.00-13.30 Lunch
13.30-15.00 Panel Discussion: Best Practices in HTPD for Regulatory Filings, Formulations, and More
Facilitator: Michael Doherty, Ring Therapeutics
15.30 Guided walking tour in Valletta (included in conference fee)
Thursday November 2 (Mediterranean Conference Center (MCC)
8.00 – 12.15 Calling All Nanoparticles: HTPD with Cells, Viral Vectors, LNPs, Gene Editors, and Vaccines
Session chair: Jack Kramarczyk, Moderna Therapeutics
8.00 – 8.15 Session intro
8.15 – 8.45 Downstream overview of an end-to-end high throughput AAV drug substance process development platform
Dr Mahsa Hadidi, Sanofi
8.45 – 9.15 Development of High-Throughput Purification Methods for Adeno-Associated Viral Vectors
Katerina Farukshina, Catapult
9.15 – 9.45 Towards High-throughput process characterization of gene therapy viral vectors
Matt Petroff, Spark Therapeutics
9.45 – 10.15 Coffee
10.15 – 10.45 Breaking boundaries in AAV platform optimisation HT monolith chromatography plate development
Nicholas Pearman, Pharmaron
10.45 – 11.15 Platform for High-Throughput Algorithmic Optimization of in vitro Transcription
Spencer McMinn, Merck
11.15 – 11.45 High-throughput Process Development for Antibody-Drug Conjugate (ADC)
Benjamin Fabre, Sanofi
12.00 - 13.15 Lunch
13.15-16.30 Frontiers in HTPD/Smart PD
Session chairs: Felix Wittkopp, Roche / Sheng-Ching Wang, Merck & Co
13.15 – 13.30 Session intro
13.30 – 14.00 Advancing High-Throughput Chromatography Development: Leveraging a QSAR Model for Experimental Design and Applying Learnings to High-Throughput Methods
Michael Rauscher, Merck
14.00 – 14.30 Smart Bioprocessing Grand Challenge
Lucie Studena, CPI
14.30 – 15.00 Coffee
15.00 – 15.30 Just because you can doesn't mean you should: What makes a successful high-throughput method
Tobias Hahn, Cytiva
15.30 – 16.00 Utilising machine learning for preventive maintenance and accelerating data analysis capabilities with digital transformation
Razwan Hanif, UCB
16.00 – 16.30 Establishment of a High-Throughput Technology Roadmap across a Global Organization to Improve Purification Process Development for Biologics
Ludivine Profit, Sanofi
19.00 Conference Gala Dinner